Adolescents less inclined to start smoking if indeed they feel linked to their parents Parents shouldn’t let up when it comes to discouraging their kids from smoking. That is the message of a report to be presented Mon, May 2, at the Pediatric Academic Societies annual meeting in Denver. Earlier research has shown that parents can deter adolescents from smoking by monitoring them and enforcing anti-smoking practices in the home. Researchers, led by E. Melinda Mahabee-Gittens, MD, a crisis medicine physician at Cincinnati Children’s Medical center INFIRMARY, sought to determine if family factors continue steadily to protect adolescents because they get older and whether these elements influence youths of varying racial/ethnic backgrounds in different ways.Further, presentations included an revise on the applications of C12-200 lipidoid-based cationic LNP formulations that achieve extremely powerful in vivo gene silencing efficacy in a non-ApoE-dependent manner. Additional findings related to the rational design of novel cationic and ionizable lipids that demonstrate improved properties for systemic delivery of RNAi therapeutics had been also reported. Finally, results were presented linked to the translation of LNPs into clinical development, including Alnylam’s ALN-VSP and ALN-TTR applications created in collaboration with Tekmira, which use an LNP formulation known as steady nucleic acid lipid particle .