Yeh found out SUMO and a couple of enzymes that remove SUMO called the SENPs a lot more than 10 years ago. SUMO and SENP are known to play important roles in heart development today, neurological diseases and cancer. Related StoriesMelatonin and the circadian rhythm: an interview with Professor Kennaway, University of AdelaideJumping genes: a marker for early cancer diagnosis? An interview with Dr KazazianGenetic carrier screening: an interview with Don Hardison, CEO of Good Begin GeneticsDr. Yeh’s group found that SENP-2 regulates a key protein called Personal computer2 that uses SUMO to improve proteins within cells and turn off gene transcription. During early advancement, SUMO-modified Computer2 binds to the suppressive code of the proteins to turn off many genes that are required for advancement of the heart and additional organs.These take less period to move through your complete system of digestion and will help you to prevent constipation by softening stool. High-fiber diets help in controlling weight also, reducing cholesterol and help you in preventing heart ailments thus, chances and weight problems of colorectal cancer while doing an effective Piles Treatment. 4. Add banana and yogurt or buttermilk in regular diet: Banana is actually a laxative and can help in loosening the stool for easy pass through rectal cavity.