In addition to reduced SOD1 activity, the flow of harmful byproducts of hemoglobin in to the spinal cord was eliminated by APC, saving neurons. Currently, the group is learning alternate types of APC, in an effort to create the proper execution that best quells the symptoms of ALS while leading to fewer unwanted side effects, such as bleeding. The experts say the proper execution of APC currently used to treat sepsis carries an elevated threat of bleeding and likely will not be appropriate for treating ALS in humans.However, event rates have risen in the last decade among male marathon runners. Clinicians evaluating potential competition participants should be aware of the risks of hypertrophic cardiomyopathy and atherosclerotic disease in this patient population.
Ying Jin, M.D., Ph.D., Stanca A. Birlea, M.D., Ph.D., Pamela R. Fain, Ph.D., Katherine Gowan, B.S., Sheri L. Riccardi, B.S., Paulene J. Holland, Christina M. Mailloux, B.S., Alexandra J.D. Sufit, B.A., Saunie M. Hutton, B.S., Anita Amadi-Myers, M.Sc., Dorothy C. Bennett, Ph.D., Margaret R. Wallace, Ph.D., Wayne T.