The first signs of the problem can become apparent within a couple of months of birth, but is more diagnosed whenever a child is 3 or 4 usually. In Britain the condition was tentatively associated with the measles, mumps and rubella vaccine in the 1990s, causing widespread concern among parents. The study that prompted the link has since been reduced and a succession of large-scale research projects has failed to establish a hyperlink between MMR and autism. Nevertheless, some parents remain concerned enough that they won’t allow their kids the MMR vaccine, which has in turn caused an increase in measles outbreaks.To eliminate confounding effects, only sufferers with the obstructive rest apnea syndrome who hadn’t previously undergone CPAP or any additional therapy for the different parts of the metabolic syndrome were recruited. Despite sufficient blinding and randomization, patients in both intervention groupings differed at baseline in regards to to key characteristics such as total cholesterol, triglyceride, and glycated hemoglobin values. Nevertheless, since this was a crossover trial, these differences should have had minimal effects on the results.